Shocking Truth About Mouthwash

Nitric Oxide: The Miracle Molecule for Good Health

Nitric oxide (NO) is a simple gas that plays a vital role in many physiological and pathological processes in the human body. It is involved in regulating blood pressure, preventing inflammation, fighting infections, enhancing memory, improving sleep, and promoting longevity. However, many factors can impair the production and availability of NO, such as aging, chronic diseases, environmental toxins, and poor oral hygiene. In this article, we will explore the importance of NO for good health, the history and recent developments of NO research, and the effects of mouthwash fluoride on NO levels.

Dr. Nathan Bryan: A Pioneer in Nitric Oxide Research

One of the leading experts in the field of NO is Dr. Nathan Bryan, a molecular medicine and nitric oxide biochemist who has been studying NO for over 20 years. He has made many seminal discoveries in the field, such as identifying nitrite and nitrate as indispensable nutrients for optimal cardiovascular health, discovering an endocrine function of NO via the formation of S-nitrosoglutathione and inorganic nitrite, and developing unique compositions of matter that can safely and effectively generate and restore NO in humans.

Dr. Bryan has also been involved in educating the public and the medical community about the benefits and applications of NO through his books, articles, podcasts, and lectures. He has appeared on several media platforms, such as The Genius Life podcast hosted by Max Lugavere, where he discussed how NO can help prevent and treat inflammation and chronic diseases, and how to optimize NO production through diet, lifestyle, and supplementation.

The History and Recent Developments of Nitric Oxide Science

NO was first identified as a gas by Joseph Priestley in 1772, but it was mostly regarded as an atmospheric pollutant for a long time. It was not until the 1980s that researchers began to uncover its role as a signaling molecule in the cardiovascular system. In 1998, the Nobel Prize in Physiology or Medicine was awarded to three pharmacologists who discovered that NO is produced by the endothelial cells that line the blood vessels, and that it acts as a vasodilator that relaxes and widens the vessels, thus lowering blood pressure and improving blood flow.

Since then, NO research has expanded to other areas of biology and medicine, revealing that NO is involved in many other functions, such as neurotransmission, immunity, inflammation, wound healing, and erectile function. NO has also been shown to have anti-aging effects, as it can protect the cells from oxidative stress, DNA damage, and senescence, and modulate the activity of several longevity-related pathways, such as sirtuins, AMPK, and mTOR.

Moreover, NO research has led to the development of various NO-based therapies and products, such as NO donors, NO-releasing biomaterials, and NO synthetic enzyme mimics. These agents can deliver or enhance NO production in a controlled and targeted manner, and have been shown to have potential benefits for treating various conditions, such as cardiovascular diseases, infections, wounds, diabetes, cancer, and neurodegenerative diseases.

How Mouthwash Fluoride Affects Nitric Oxide Levels

One of the factors that can affect NO levels in the body is oral hygiene. The oral microbiome, or the community of bacteria that live in the mouth, plays a key role in converting dietary nitrate, which is found in vegetables, into nitrite, which is then converted into NO in the stomach and the blood vessels. This process is essential for maintaining healthy blood pressure and preventing cardiovascular diseases.

However, the use of mouthwash, especially those that contain an antiseptic compound called chlorhexidine, can disrupt the oral microbiome and kill the beneficial bacteria that produce nitrite. This can result in a significant reduction of oral and systemic NO levels, and a corresponding increase in blood pressure and cardiovascular risk.

Fluoride, which is added to some mouthwashes and toothpastes to prevent tooth decay, can also have a negative impact on NO levels. Fluoride can inhibit the activity of nitric oxide synthase, the enzyme that converts L-arginine into NO in the endothelial cells and other tissues. This can impair the production and availability of NO, and lead to endothelial dysfunction, inflammation, and oxidative stress.

Therefore, it is important to choose oral hygiene products that are gentle and natural, and that do not interfere with the oral microbiome and NO production. It is also advisable to consume more nitrate-rich vegetables, such as leafy greens, beets, and celery, to boost NO levels and support cardiovascular health.

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NO is a remarkable molecule that has many benefits for good health and longevity. However, its production and availability can be compromised by various factors, such as aging, chronic diseases, environmental toxins, and poor oral hygiene. Therefore, it is essential to adopt a healthy diet, lifestyle, and oral care routine that can optimize NO levels and prevent NO deficiency. By doing so, we can enjoy the positive effects of NO on our heart, brain, immune system, and overall well-being.

Learn more

About – Dr. Nathan Bryan – Molecular medicine and nitric oxide biochemistry. (https://drnathansbryan.com/about/)
YouTube – Dr. Nathan Bryan | Max Lugavere – The Genius Life, podcast:
(https://youtu.be/qGVLqLxAl0I?si=tb-4yh-z7-AfMc0m)
Wikipedia – Nitric oxide (https://en.wikipedia.org/wiki/Nitric_oxide)

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